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Copyright
© Asian Journal of Ophthalmology, 2016
Affiliations
Aggeliki Kolea
Department of Ophthalmology, Agios Dimitrios General Hospital, Thessaloniki
Aggelos Baltatzidis
of
Radiology, AHEPA Hospital, Aristotle University, Thessaloniki
Vasileios Margaritis
Department of Ophthalmology, Agios Dimitrios General Hospital, Thessaloniki
Belal Almoghrabi
Department of Ophthalmology, Agios Dimitrios General Hospital, Thessaloniki
Irini Kaldi
Department of Ophthalmology, Agios Dimitrios General Hospital, Thessaloniki
Alexandros Polychronakos
Department of Ophthalmology, Agios Dimitrios General Hospital, Thessaloniki
How to Cite
Acute Visual Loss as a First Sign of Hyperhomocysteinaemia
- Aggeliki Kolea ,
- Aggelos Baltatzidis ,
- Vasileios Margaritis ,
- Belal Almoghrabi ,
- Irini Kaldi ,
- Alexandros Polychronakos
Vol 12 No 3 (2011)
Submitted: Feb 11, 2016
Published:
Abstract
A 38-year-old man presented with an acute right homonymous visual field defect due to occipital lobe infarct caused by hyperhomocysteinaemia. Visual field testing, magnetic resonance imaging, laboratory studies, and genetic analysis were carried out. On magnetic resonance imaging, a left occipital lesion with bright signal on the diffusion-weighted and fluid-attenuated inversion recovery images suggested a diagnosis of an acute infarct. Blood tests revealed raised homocysteine of 52.08 μmol/L (reference range, <15 μmol/L) and genetic analysis showed the patient to be homozygote to 5, 10-methylenetetrahydrofolate reductase deficiency. Hyperhomocysteinaemia is a rare causes of acute visual loss due to cerebral ischaemia and should always be suspected and investigated with the appropriate tests to diagnose the condition and limit further vision deterioration.